Are DNA Repair Enzymes Worth It? A Dermatologist’s Perspective

🧬 Can skincare really repair your DNA? In this video, Dr. Dray, board-certified dermatologist, breaks down the science behind DNA repair enzymes in skincare products—what they do, how they work, and whether they’re actually safe and effective.

If you've heard about products that claim to reverse sun damage or repair DNA, you might be wondering: is that even possible? In this deep-dive, we explore the clinical evidence, delivery mechanisms like liposomes, safety data, and how these enzymes could complement sunscreen for more complete photoprotection.

🔍 In this video, you’ll learn:

0:00 – Intro
1:37 – Do DNA repair enzymes actually work?
2:30 – How do they get into the skin?
5:32 – Are they safe?
7:10 – Who should consider using them?
8:40 – Final thoughts & recommendations

📚 Scientific References Discussed:
Kabir et al. (2015), J Drugs Dermatol
Megna et al. (2017), G Ital Dermatol Venereol
Rosenthal et al. (2019), J Eur Acad Dermatol Venereol
Wolf et al. (2000), J Invest Dermatol

🧴 Sunscreens Containing DNA Repair Enzymes:

FTC: This video is not sponsored. Links are commissionable, meaning I may earn commission from purchases made through links.

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Disclaimer: This video is not intended to provide diagnosis, treatment or medical advice. Content provided on this Youtube channel is for informational purposes only. Please consult with a physician or other healthcare professional regarding any medical or health related diagnosis or treatment options. Information on this Youtube channel should not be considered as a substitute for advice from a healthcare professional. The statements made about specific products throughout this video are not to diagnose, treat, cure or prevent disease.

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28 Comments

    1. Yes! Been using it for 2 years and really like it, but is it actually doing anything? Please Dr. Dray, review this product.

    2. I hope she does review it. I used it for almost a year and saw no change in my skin. It was an expensive product. I would only consider buying again if she reviews it and likes it.

  1. Do you think it has potential to help repair damage in the skim caused by other factors beyond UV? For example, damage caused by inflammation (cystic acne), oil oxidation, internal factors, etc

  2. Thank you for doing this video as I currently use this sunscreen and I also alternate with La Roche Posay sunscreen SPF 50, thank you and really appreciate all the knowledge you share with us.

  3. While there are some pricey DNA repair enzyme serums, you may already have a skincare product with a DNA repair enzyme or two in it (micrococcus lysate, plankton [best used during the day], lactobacillus ferment extract, etc).

  4. Skin cancer is prevalent in my family, and my mature skin was starting to get a lot of pre-cancerous and basal cell cancers. I started using Photozyme DNA youth recovery serum (with 3 repair enzymes) about a year ago and no new bumps/patches! Hard to say how much it’s helping with anti-aging since I use other products for that as well, including retinal. But it’s a nice lightweight fluid that serves as a.m. moisturizer under sunscreen. It’s very pricey but they have 35% off coupons from time to time. I figure it’s less expensive than getting a bunch of skin cancers treated! 🤞👍🙏

  5. heeey, I asked you about it a few videos ago. Happy to listen about it deeper. Thank you, Dr. Dray ♥

  6. I had the same question when I picked the tinted up at Sephora. I returned it due to the poor color match. Plus I was not sure about the DNA claim. For the price I felt more explanation was needed.

  7. I was introduced to Isdin and the potential for repair of skin damage through a previous video of yours. I purchased the Isdin to see if I saw any benefit to the thinness of my forearms and chest. After 4 months of continual use, the skin on my forearms felt thicker and more resistant to everyday damage from chores and gardening. It’s expensive but I will purchase it again. Thank you for vetting items like this for us!

  8. I appreciate videos like this so much. Lately I’ve been exploring how beauty is more than just products…and The Forbidden Art of Majestic Beauty completely blew my mind. It talks about things I never thought mattered, like the intention behind how you walk into a room, or how your energy affects your appearance more than we realize. After trying a few techniques, I started getting compliments without changing anything about my makeup. That book is a hidden gem

  9. You’re teaching me something new, Dr Dray. I haven’t heard of DNA repairing enzymes in skin care. Interesting information. Thanks so much! Happy Tuesday!! I hope you have a lovely evening. 💙

  10. I’ve been having good success with Regelica. I got it on sale. The bottle lasts a long time. I’m super happy because I have sensitive skin. My sebaceous hyperplasia have improved!!!

  11. I’ve used a number of Photozyme products and have a few favourites. The Youth Recovery I’ve repurchased because I like using it before my LED mask. I’ve just ordered one of the ISDIN sunscreens and am looking forward to trying it.

  12. I use Photozyme serum and really like it. My skin is already in good condition for my age (53) because of Tretinoin use since my early 20s and using SPF daily since 30. I started using Photozyme and My Alloy estradiol cream at roughly the same time and my skin got even better hard -to know which product to attribute this to. Photozyme is very pleasant to use and a bottle lasts me 4 months so the price really isn’t that bad. Even with Photozyme and My Alloy, my annual skincare budget is under $120 a month. that may seem high to some people but I think it is worth it because I barely have any wrinkles, have pretty even skin tone and I don’t get Botox, fillers, peels or lasers.

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